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doi: 10.4103/pigmentinternational.pigmentinternational_29_21 81 PeiJPanXWeiGHuaY

Although many patients notice symptomatic weakness, major weakness on examination is only observed in later stages of advanced diabetic neuropathy

Based on the derived sensitivity and specificity, performance metrics including positive predictive value, negative predictive value, number needed to screen, and number proceeding to PET scan were calculated based on a prevalence of amyloid PET positivity of 25% 31

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Given its mechano- and chemo-sensitivity, NOX2-mediated ROS production increases progressively with the onset and intensity of exercise

However, the decrease in metabolic efficiency also leads to reduced chemotaxis and phagocytic functions of microglia [6, 115]