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Abstract Astrocytes have traditionally been cast as supportive glia, but they are increasingly recognized as metabolic hubs that regulate cholesterol synthesis, fatty acid detoxification, lipid droplet dynamics and redox homeostasis in the CNS

S dng ng liu: Bn cn tun th hng dn v s dng ng liu lng c ch nh bi bc s

Multiple factors including oxidative stress, mitochondrial impairment, lysosomal or proteasomal dysfunction, and glutathione (GSH) depletion are thought to contribute to the pathogenesis of PD

Muscle recovery and body composition changes take longer to accumulate

Similarly, the Modified Shoutai Pill (Jianwei Shoutai Pill, JSP) upregulates GPX4 and GSH levels while decreasing MDA and ACSL4 protein expression, thereby mitigating lipid metabolism disorders in recurrent pregnancy loss models [99]

Simultaneously, some cells undergo cell cycle arrest and become senescent owing to the inhibition of cyclin-dependent kinases mediated by p21 activation through the DDR pathway 11