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The combination of AMP with other biomaterials will not only eliminate drug-resistant bacteria but will prevent resistant development and enhance the individual biomaterials therapeutic effects

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Because CMX157 is cleaved intracellularly by phospholipase C and/or sphingomyelinase, the nephrotoxicity seen by other tenofovir prodrugs cleaved in plasma may be decreased, and with the aforementioned additive or synergistic behavior, CMX157 may be an intelligent choice to pair with currently approved antivirals to move forward through Phase III studies

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Liu J, Yan L, Yang W et al (2019a) Controlled-release neurotensin-loaded silk fibroin dressings improve wound healing in diabetic rat model