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Experimental evidence revealed a significant increase in KEAP1-RBM45 binding in cytosolic fractions from ALS lumbar postmortem spinal cord compared to controls

Aliment Pharmacol Ther 25:14431449 Funding This work is financially supported from Traditional Chinese Medicine Technology Project of Jinhua (2025QN04), Scientific Research Project of Jinhua Advanced Research Institute (G202408), Key Research and Development Special Project of Henan Provincial Science and Technology (242102231050), and Major Science research Project of Zhengzhou Railway Vocational and Technical College (2024KY001)

Curcumin also strengthens barrier integrity by upregulating tight junction proteins (ZO-1, occludin, claudin-1), thereby limiting lipopolysaccharide (LPS) translocation and systemic inflammation (Burge et al., 2019

5-amino-1mq appears to have muscle-sparing properties

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