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The leave-one-out results suggest that the causal effect was not driven by single instrumental variable (Supplementary Figures 1, 2)

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Dhaval Bhanusali, M.D., notes that vitamin C can be irritating, particularly on sensitive, acne-prone skin or conditions like rosacea, so slowly introducing it is vital

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The reaction mixtures were then centrifuged for 5 min at 6000 g and the supernatants assayed for DNA oxidation with an 8-hydroxy-2-deoxyguanosine (8-OHdG) ELISA assay (Cell Biolabs, CA, USA)