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, Tan, M

In addition, lysine demethylase 4C (KDM4C) can also increase the expression of SSP genes by directly demethylating the promoter of SSP genes or ATF4, a transcriptional substrate of NRF2 (Denicola et al., 2015

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PMID: 29688333
52 It has been suggested that there can even be signs of cellular metabolic stress that precede dementia and that this can and should be observed in these patients

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