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The roles of lipids in modulating host immune response, either in promoting or eliminating inflammation, have been of major clinical interest ( in vivo , fatty acid (FA) utilization by -oxidation is a major bioenergetic pathway that could be upregulated with prolonged fasting, exercise, or metabolic stress

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87 Moreover, -alanine, a non-essential amino acid structurally similar to lactate, suppresses breast cancer tumorigenesis by competing with lactate for binding to AARS1 to interfere with p53 lactylation