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Zoeller, Thresholds and endocrine disruptors: an Endocrine Society Policy perspective

Methotrexate, an antifolate drug used in cancer therapy, is a known inhibitor of DHFR, the enzyme that catalyzes the conversion of DHF into THF, which is required for the de novo synthesis of nucleotides for both DNA and RNA

doi: 10.1016/j.cgh.2012.03.011 [DOI] [PubMed] [Google Scholar] 55.Du SX, Lu LL, Geng N, Victor DW, Chen LZ, Wang C, et al

However, sustained high doses, overdose, fasting, alcohol use, or pre-existing liver disease can overwhelm glutathione reserves, increasing risk of hepatotoxicity and oxidative stress

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Role of Surgery as Local Consolidative Therapy for NSCLC