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Recent studies have explored small-molecule inducers, selenium-based compounds, and targeted nanodelivery approaches to restore GPX4 function or mimic its antioxidant capacity in ferroptosis-prone diseases, with therapeutic implications for OA and beyond ( In summary, GPX4 acts not only as a terminal antioxidant enzyme but also as a hub that integrates transcriptional, post-transcriptional, and nutritional cues

Metabolic plasticity as a resistance mechanism Beyond these biological paradoxes, the clinical failure of metabolic-targeting therapies underscores another key barrier: the extraordinary metabolic adaptability of cancer cells [320]

B12 shots, also referred to as Vitamin B12 injections or cobalamin injections, are a type of vitamin supplement injected directly into the body

This review systematically examines the mechanisms of metformin in ameliorating PCOS-associated infertility, with particular emphasis on its pleiotropic effects across critical life stagesfrom pubertal development through pregnancy to long-term health outcomes, thereby providing valuable insights into the clinical application of metformin in the treatment of PCOS

Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway

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