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10.1038/s41418-020-00644-4 402 WangL.LiK.LinX.YaoZ.WangS.XiongX.et al (2019a)

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(139) confirmed in 2023 that serum BCAA levels can serve as effective indicators of DKD, with BCAA levels beginning to decline in the microalbuminuria stage and further declining in the macroalbuminuria stage, negatively correlated with urinary microalbumin levels and positively correlated with serum albumin levels, indicating that BCAAs are closely related to nutritional status in T2DM patients

Efforts should therefore broaden the applicability of such combination regimens across diverse cancer histologies, leverage multi-omics data, next-generation pre-clinical models and artificial intelligence to accelerate the closed-loop translation from mechanism biomarker therapy

Brookings Institution

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