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established a direct neurotoxic action by acetaminophen both in vitro and in vivo in rats at doses below those required to produce hepatotoxicity and suggested that this neurotoxicity might be involved in the general toxic syndrome observed during patient acetaminophen overdose and, possibly, when acetaminophen doses in the upper dosing schedule are used, especially if other risk factors (moderate alcohol drinking, fasting, nutritional impairment) are present

10.3390/ijerph19010207 154

However, a few important questions remain to be answered for the effective clinical application of ferroptosis-focused treatments

The most important with curcumin is bioavailability

Chen D, Zhang G, Li R, Guan M, Wang X, Zou T, et al

Impaired glutamate uptake leads to extracellular accumulation, triggering the overactivation of AMPA and NMDA receptors and driving neuronal hyperexcitability