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TLR3-based directed evolution approach Huh7 neoJFH1 cells 34 were reversely transduced with lentiviral particles encoding either TLR3 or empty control

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When taken in large amounts, it can make skin an orange-brown color

Following identification in the early 1990s (139, 140), CD80/86 were first used as DNA-encoded adjuvants in 1997, recognized for their ability to induce cellular responses