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For instance, short-chain fatty acids (SCFAs) and secondary bile acids have been reported to regulate redox balance, energy production, and activate AMP-activated protein kinasesa proposed connection linking SCFAs to mitochondrial biogenesis (Donohoe et al., 2011
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Therefore, pharmacological agents that mimic or enhance irisin signalingsuch as stable irisin analogs or small-molecule agonistsmay offer a viable alternative for maintaining therapeutic levels without relying solely on physical exercise
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