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MODY1 results from mutations in the gene (HNF4A) encoding the transcription factor identified as hepatic nuclear factor-4 (HNF-4)

Low-dose 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine causes inflammatory activation of astrocytes in nuclear factor-B reporter mice prior to loss of dopaminergic neurons

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Captopril, an angiotensin-converting enzyme inhibitor, is widely used in clinical practice to treat hypertension, MI, and congestive heart failure and is effective in attenuating left ventricular (LV) dilatation, ameliorating LV ejection fraction and improving cardiovascular morbidity and mortality [237, 238]

This multi-layered conceptualization of wounds mandates therapeutic approaches addressing all spheres, setting the stage for integrative models of care