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Based on these and other observations, it was proposed that cytosolic GGC, rather than vacuolar or extracellular GGT, is the major enzyme initiating GSH degradation and that this route could be particularly important in the intercellular transport function of GSH (Ohkamu-Ohtsu et al., 2008)

Brain PP2A is modified by thiol-disulfide exchange and intermolecular disulfide formation

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However, other stimuli such as asbestos, silica and hydrogen peroxide have been shown to induce ROS-mediated NLRP3 inflammasome activation in human monocyte-derived macrophages and THP-1 monocytic cell lines 50,51

Fong JT, Jacobs RJ, Moravec DN, Uppada SB, Botting GM, Nlend M, et al

Poor membrane health is associated with chronic illness