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In the chronic toxicity experiment, L-NAME caused severe tissue damage (myocardial and hepatic cell necrosis, necrosis of the lymphoid cells in the spleen) while L-arginine provoked predominantly congestion, edema and hemorrhages in all organs

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It is not improved by diet or exercise, and a medication is in development to help lower it

Vasoactive Intestinal Peptide (VIP) is also used for nerve-related pain and inflammation

In LNCaP cells, oxymetazoline demonstrated more potent ERK 1/2 activation than treatment with noradrenaline, behavior that is commonly observed with -arrestins biased agonists