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16 Cyclic loading during culture period is generally superior to no or static loading, probably because it enhances fluid flow and cell nutrition, but also because it directly exerts a mechanobiological stimulus on cells

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(1977) Improvement of cis-dichlorodiammineplatinum (NSC-119875): Therapeutic index in an animal model

This modification regulates proteins involved in metabolism (glyceraldehyde-3-phosphate dehydrogenase, pyruvate kinase), signal transduction (protein kinases, phosphatases), transcription (NF-B, AP-1), cytoskeletal dynamics (actin), and apoptosis (caspases)

Shalet et al., 1978), the majority showed impaired GH secretion within 1 or 2 years