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The care and handling of the animals were carried out according to standard guidelines and under Animal Research: Reporting of In Vivo Experiments guidelines

8 weeks 2 x 10 mL bottles 5 vials use 15 mL total

doi: 10.1590/s0102-0536-20210412 22

However, their efficiency in DS patients is limited, showing the need to combine multiple therapies to improve cognitive deficits and more generally the quality of life of DS patients

Targeting such signaling pathways to regulate ferroptosis and autophagy synergistically may be explored to leverage their anti-tumor or drug-resistance reversal effects to a greater extent