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This oxidative damage is particularly severe in the substantia nigra in PD, where dopamine-producing neurons are especially vulnerable to ROS ( 2.4 Neuroinflammation Neuroinflammation is another critical factor in the progression of neurodegenerative diseases

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Chen C-M, Wu Y-R, Cheng M-L et al (2007) Increased oxidative damage and mitochondrial abnormalities in the peripheral blood of Huntingtons disease patients

It is worth mentioning that there have been reports of isolated cases in which bodybuilders developed long-term adverse effects, including squamous cell carcinoma in the lung and bilateral laryngoceles (Moor and Khan, 2005