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All animals were acclimatized to the laboratory conditions for 7 days before the beginning of the experiments

Role of P-glycoprotein in pharmacokinetics

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Moreover, as previously discussed, in a cecal ligation and puncture (CLP)-induced polymicrobial sepsis model, the conditional depletion of GPX4 triggers excessive lipid peroxidation and aggravates systemic inflammatory response that reportedly rely on GSDMD-dependent pyroptosis rather than ferroptosis [12]