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Truter, M., Schaeffner, B.C., & Smit, N.J

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Related experiments have confirmed that HO-1 effectively inhibits IkB phosphorylation and its subsequent degradation, leading to NF-B translocation and downstream inflammatory gene transcription reduction, which indicates that CGA activates Nrf2/HO-1 and inhibit NF-B (52)

Real-world use of similar GLP-1 receptor agonists like liraglutide and semaglutide extends beyond 5 years in some patients