glutathione plus transdermal cream springboard Molecules | October-2 2023 Glutathione Cream

Co-treatment with NO and H 2 S donors downregulates P-glycoprotein (MDR1), reducing chemotherapeutic efflux and resensitizing tumors to conventional agents

SA: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Project administration, Resources, Visualization, Writingoriginal draft

Along with the above changes, chronic inflammation also compromises the integrity of the BBB, increasing permeability and making the CNS more vulnerable as a result of the entry of cytokines such as IL-1, IL-6, and TNF-, and immune cells from the systemic circulation, which are normally strictly regulated

For this reason, GSH implementation should not be used in drug-induced toxicities different than platinum-related neurotoxicity, that at this moment represents its only clinical indication

Consulting a healthcare professional to determine the most suitable administration route is advisable for optimal results

Eddleston M, Buckley N, Checketts H, Senarathna L, Mohamed F, Sheriff M, Dawson A