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Any references to biochemical pathways, receptor interactions, or enzymatic processes are provided solely for informational and research-context purposes

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Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy

Endogenous (e.g., inflammation) and exogenous (e.g., diet components, toxicants, or drugs) factors can increase intestinal permeability and cause the formation of a so-called leaky gut. The latter is characterized by the penetration of food antigens, commensals, or pathogenic bacteria into the blood, causing the development of inflammation (Vanuytsel et al., 2021)