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The importance for conserving thiol bonds is evident when one understands that incorporation of a cysteine moiety influences the tertiary structure of proteins (e.g., molecule configuration, folding) and can influence effects of certain drugs (e.g., insulin)

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150 million diabetic individuals are estimated to receive the drug regularly worldwide[25]

Despite recent developments in the field of metal-based catalytic drugs, these compounds are generally associated with a poor spatial and temporal control of the treatment as well as poor cancer selectivity, resulting in potential side effects and non-ideal drug doses 29

Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme