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Doing so can help to ease symptoms such as sleep disruption, fatigue, irritability, and mild depression
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Proanthocyanidins and hydrolysable tannins: Occurrence, dietary intake and pharmacological effects

Even in picogram quantities, they can elicit strong inflammatory and cytotoxic responses in mammalian cells, confounding experimental results

[136] Liss MA, Dursun F, Hackman GL, et al