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ECG Recording ECGs were recorded continuously in deeply anesthetized rats for all three main leads by positioning stainless steel electrodes on all four limbs using an ECG monitor with a 2090 programmer (Medtronic, Minneapolis, MN, USA) connected to a Waverunner LT342 digital oscilloscope (LeCroy, Chestnut Ridge, NY, USA) before procedure, after ligation and therapy application, and before sacrifice

doi: 10.1016/j.neuroimage.2010.11.089

LeMaistre Distinguished Chair in Thoracic Oncology, Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX Professor, Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX Research Interests An author of more than 260 peer-reviewed publications, Dr
( Figure 1 AngII can also be converted to Ang(17) by Carb-P cleavage of Phe ( 2 ( 1 and AT 2 receptor subtypes and mediate pressor and dipsogenic functions [Figure 2

This issue has been vigorously debated because of examples in the literature, where peripheral measures either failed to adequately reflect central pathophysiology or did not serve as reliable biological markers
The chemical reaction involves the deprotonation of C4 in the A ring of the steroid substrate, thereby enabling the double bond between C5 and C6 to isomerize to a double bond between C4 and C5 (Figure 2)