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Finally, recent work has demonstrated that mitochondrial DNA (mtDNA) released into the cytosol serves as a signal to activate the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway (37)

There are also secondary mitochondrial diseases that are induced by abnormal processes not related to OXPHOS that can have both inherited and acquired causes, such as aging and inflammation [93], but these will not be covered in this review

However, components 2 and 3 accounted for a lower proportion of 6.2% and 4.2%, respectively, compared to component 1

Accessed online at Penning R, van Nuland M, Fliervoet LAL, Olivier B, Verster JC

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