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d-Limonene complexed with cyclodextrin attenuates cardiac arrhythmias in an experimental model of doxorubicin-induced cardiotoxicity: Possible involvement of calcium/calmodulin-dependent protein kinase type II

Its biological profile resembles genomic regulation more than classical growth-factor stimulation

For small molecules, refer to ICH guidance S2(R1) for recommendations on genotoxicity testing, which does not apply to biologics.9 Initially, a gene mutation assay (e.g., in vitro Ames test) will support a singledose trial

10.1126/scitranslmed.3001387 [DOI] [PubMed] [Google Scholar] Culp M

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For some people, medication may be helpful