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Thus, LPS and IL-6 can activate the M1 phenotype, and IL-10 acts as an anti-inflammatory cytokine through the modulation of STAT1 and STAT3 signalling [352]
Current studies in PF face key gaps, including the lack of standardized, dynamic EMT assessment, limited translational relevance of acute injury models to human idiopathic PF, and insufficient integration of emerging mechanisms such as ferroptosis, metabolic reprogramming, and mechano-signaling
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Vega-Lpez et al
1992 November 17
