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One risk is that if too much cartilage is removed, the nose will appear abnormal, and the function can be impaired

In castration resistant prostate cancer, a clinical trial rechallenged patients with abiraterone at a lower dose once prostate specific antigen levels returned to baseline rather than continuous treatment at a higher dose (Gallaher et al., 2018)

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In the experimental period, the low-dose groups (A2 and C) were administered 50 mg/kg l-carnitine via intraperitoneal injection once a day, and the high-dose groups (A3 and D) were given 100 mg/kg

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