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Description
Autosomal-dominant hypercholesterolemia can also be caused by increased activity of a protease, proprotein convertase subtilisin/kexin type 9 (PCSK9), which promotes degradation of the receptor, and by defects in apo B-100 that reduce its binding to the receptor.] [3] The vesicle containing LDL loses its clathrin coat and fuses with other similar vesicles, forming larger vesicles called endosomes
Joshua Rocker MD, Cohen Childrens Medical Center, New Hyde Park, NY
As a member of the Barcelona Health Hub, in the Modernist Sant Pau, he promotes excellence and development in the health sector.
Acknowledgements We thank Barbara Bonn, Janis Moeller and Sabine Eisner for excellent technical support
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therefore, no adherence monitoring strategies could be implemented
