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Forelimb grip strength was chosen to measure muscle function since it has been repeatedly shown that C57BL/6 mouse forelimb grip strength begins to decline at or before 24 months of age 18,19,20

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These medications work by mimicking glucagon-like peptide-1, a hormone naturally produced by the body that plays a key role in appetite regulation, digestion, and metabolic function

Water fluctuations, muscle changes, and timing of measurements create noise that obscures actual fat loss

The mechanism is slow because it works by reprogramming fat cells, not by suppressing appetite