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Metformin increases the radiosensitivity of non-small cell lung cancer cells by destabilizing NRF2

Ferroptosis suppressor protein 1 (FSP1), originally identified as apoptosis-inducing factor mitochondria-associated 2 (AIFM2), was rediscovered through unbiased genetic screens as a potent GPX4-independent ferroptosis inhibitor (96)

Mechanistically, the reductive stress observed in R120G mutant mice was attributed to activation of the nuclear factor (erythroid-derived 2)-like 2 (NRF-2) signaling pathway, which transcriptionally upregulated the mRNA or/and protein expression of key antioxidant enzymes ( e.g

Guillemette C, De Vivo I, Hankinson SE, Haiman CA, Spiegelman D, Housman DE et al

Consequently, we assessed the ATG2A/ZDHHC11 colocalization in relation to Lipi-Blue-labeled LDs

doi: 10.1111/febs.14466 73 DavidBAKubesP
