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However, for individuals actively managing complex, reactive chronic illnesses like Long COVID, ME/CFS, or severe dysautonomia, such high starting doses are rarely recommended due to the high potential for gastrointestinal upset or rapid, uncomfortable detoxification reactions (often referred to as a Herxheimer reaction)

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doi: 10.1016/j.celrep.2016.09.054

Zinc : Zinc is often better tolerated when taken with a light meal to prevent any potential stomach upset

3.3.2 Cortisol Cortisol, a glucocorticoid hormone associated with stress, usually increases during fasting to maintain glucose homeostasis through mechanisms such as gluconeogenesis and increased fat utilization [44]

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