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They hypothesized that cysteine deprivation impairs the ETC activity and Krebs cycle, leading to hyperpolarization of the IMM followed by lipid peroxidation [230]

The discrepancies between these studies stem from differences in age, the period of risk analyzed (start of treatment or maintenance of treatment), and the way in which confounding factors (cardiovascular history, smoking) were controlled

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There is theoretical bleeding risk in patients with thrombocytopenia and coagulopathy, though this risk is likely low

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