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It disrupts sleep architecture and suppresses growth hormone release during the first sleep cycle

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Ceccarelli M, Venanzi Rullo E, Berretta M, Cacopardo B, Pellican GF, Nunnari G, et al

Copper plays a role in multiple aspects of HIF-1 regulation, including the stabilization of HIF-1, formation of transcriptional complexes and binding to hypoxia-responsive element (HRE) sequences of target genes (50)