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However, excessive ROS due to the imbalance of generation and scavenging can attack cellular molecules and cause a variety of pathological damage 2,4 , leading to many diseases including cancer, diabetes, heart disease, and some neurodegenerative diseases 3,5,6
Surprisingly, these analyses revealed that many normal non-transformed mammalian cell types can proliferate without any cyclin D-CDK4/6 activity (7, 8)

doi: 10.1252/jcej.5.27

A comprehensive study on the composition of amino acids under Cu stress was done by Irtelli et al
M.WeinhausR
