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Redox Biol Dissecting the process of human neutrophil lineage determination by using alpha-lipoic acid inducing neutrophil deficiency model

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doi: 10.1073/pnas.0735876100

The classical NF-B pathway is activated within minutes after exposure to proinflammatory signals, and involves TGF- associated kinase 1 (TAK1)-mediated activation of the IKK complex (consisting of catalytic (IKK and IKK) and regulatory (IKK) subunits), which mediates the phosphorylation and subsequent degradation of IB (an IB family protein), leading to the nuclear translocation of the NF-B heterodimer RelA/p50

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