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Kojic acid or arbutin can boost the brightening benefits

2025 Apr;242(4):717-724

There is a theoretical --- though as yet unproven in humans --- risk that long-term or high-dose use could stimulate growth in existing malignant or pre-malignant cells

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Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion
