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These effects were blocked by sulfasalazine, an inhibitor of the xCT transporter, which incorporates cystine (precursor of GSH) and extrudes extracellular glutamate, an agonist of the inhibitory mGlu2/3 receptor, which lowers the synaptic glutamatergic tone

PPI network analysis PPI network analysis was performed on 38 genes identified using the STRING database with an FDR threshold of 0.05, revealing that 11 of the 38 genes were attributed to the co-expression of genes based on publicly available datasets (Fig

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H N 0 HEN 0.- H 1) The neuroactive dipeptide L-tyrosyl-L-arginine (Kyotorphin) was discovered to have important role in the regulation of pain

The entire selection pathway is described in the Results section and is visualized in the standard PRISMA flow diagram [Figure 1]