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This paper was developed as part of the GBD Collaborator Network and GBD Protocol with support from the GBD Secretariat, IHME and the GBD Collaborator Network under the IHME ID: 4251 (GBD 2023 Substance Use Collaborators)

Brain Commun 6: fcad349, 2024

doi: 10.1016/j.foodchem.2008.05.030

First, PPIs disrupt the gastric acid barrier, allowing exogenous bacteria, particularly acid-resistant bacteria, to enter the gastrointestinal tract easily (Martinsen et al., 2019)

As the RIPK1-targeted inhibitor of necroptosis, necrostatin-1 could both rescue the ferroptosis and necroptosis of RPE cells via inhibiting RIPK1/RIPK3 activation and lipid ROS accumulation (Tong et al., 2023)

No clinically validated dosing regimen exists for BPC-157