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There is currently no established treatment for MAFLD and MASH other than interventions that encourage lifestyle changes and the use of medicines to control or treat metabolic disorders (95, 96)

Understanding the underlying causes, whether related to the Vitamin B12 molecule or contaminants, is crucial for improving the safety and efficacy of these injections

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Some patients and practitioners opt for a combination approach: compounded tirzepatide with glycine and B12 in the injection, plus oral niacinamide supplementation separately