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This is rare with MT-II at standard doses but possible

According to Tajik et al., gut dysbiosis directly triggers zonulin secretion by intestinal epithelial cells and induces zonulin-mediated downregulation of TJ proteins (ZO-1, occluding, and claudin-1) [2]

Standard medical dosing for confirmed deficiency typically involves an initial loading phase followed by maintenance

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doi: 10.1016/j.cell.2017.02.031 [DOI] [PMC free article] [PubMed] [Google Scholar] 85.Zhang C, Xie Y, Chen H, et al

Lenny Macrina: They did talk about HGH and EPO as similar peptides and their side effects, but then the authors went online, and they looked at what people reported anonymously on websites and stuff like that