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While the clinical manifestations and target organs differ, a common thread linking conditions such as Sjgren's syndrome (SS), RA, SLE and multiple sclerosis (MS) is the breakdown of immune tolerance triggered by genomic instability (42,123,124), The main core mechanisms involved in various autoimmune diseases include the sustained accumulation of oxidative DNA damage, functional defects in specific repair genes, resulting abnormal accumulation of cytoplasmic DNA, and ultimately excessive type I interference response and chronic inflammation triggered by innate immune sensing pathways such as cGAS STING

Klintworth et al., 2007), 6-OHDA (von Coelln et al., 2001), and MPP+ (Itano and Nomura, 1995

These findings demonstrate that heat stress progressively impairs sperm viability, acrosome integrity, and chromatin structure, whereas niacin, particularly at the higher dose, provides time-dependent and dose-dependent protection, mitigating heat-induced reproductive damage

Abstract With the increasing prevalence of alcohol-related diseases, expanding our understanding of the toxic effects of excessive alcohol consumption is critical for prevention and treatment of metabolic and inflammatory pathology

EP patent 79,241 Hamazawa K, Maegawa H, Furue S (1998) NAD and glutathione high content yeast

This class of drugs are not new but have gained attention recently as an effective treatment for obesity and type 2 diabetes (133135)