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Our findings are consistent with these previous observations

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doi: 10.12056/j.issn.1006-2785.2019.41.22.2019-2290 41 PludowskiPKos-KudlaBWalczakMFalAZozulinska-ZiolkiewiczDSieroszewskiPet al

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Since three reactions of the TCA cycle as well as PDH utilize NAD + as co-factor it is not difficult to understand why the cellular ratio of NAD + /NADH has a major impact on the flux of carbon through the TCA cycle

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