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Hartman et al

We next examined the Zn 2+ -dependent proteome of AH and screened it for the proteins capable of mediating cytotoxic signals of zinc, among which pigment epithelium-derived factor (PEDF) was the most relevant candidate

Murray RK, Bender DA, Botham KM, Kennelly PJ, Rodwell VW, Weil PA

They accomplish this task in vastly different, yet complementary ways
