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Our recent genome-wide ChIP-Seq global study also found that NRF2 directly regulates genes involved in PPP along with focal adhesion pathways in A549 NSCLC cells.61 The genes associated with the focal adhesion pathway can promote glucose consumption, lipogenesis and glutamine dependence, ultimately leading to the promotion of tumor growth.62 To shed light on the metabolic features of NRF2-activated lung cancers, Saigusa et al
In summary, the integration of traditional Chinese medicinal approaches with contemporary drug delivery systems offers a novel strategy for the targeted treatment of glioma
In humans, this enzyme family serves as one of the critical antioxidant mechanisms, readily scavenging reactive oxides and peroxides that are naturally or exogenously produced, protecting cells and structures from oxidative damage 31
Nature 496, 101105
Globus pallidus interna or subthalamic nucleus deep brain stimulation for Parkinson disease: a review
Lower levels are associated with reduced cellular energy, increased oxidative stress, and slower metabolic processes
