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Topical mequinol/tretinoin was shown to be noninferior to 4% HQ as 81 and 85 percent of patients experienced clinical success on the mequinol-treated and the HQ-treated sides of the face, respectively

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Genome Biol 15:R89

B12 absorption decreases with age due to reduced production of intrinsic factor, a stomach protein needed for absorption

Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

It has not been linked to any notable side effects or toxicity, whether applied topically or via subcutaneous injection