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10 M retinoic acid was used as a positive control for maturation towards a differentiated neuronal phenotype, as shown previously ( 2.2 DPI synergizes with MitoQ in MNA NB cells To assess whether MitoQ and DPI act synergistically in reducing cell viability, we treated two MNA NB cell lines (IMR-5/75 and Be(2)-C) with various concentrations of DPI and MitoQ

The Stockwell group identified a novel small molecule, erastin, through a high-throughput screen for synthetic lethal compounds in 2003, which induced a nonapoptotic form of cell death [17]

These findings underscore the vital role of natural products in developing next-generation anti-fibrotic therapies, providing new sources and reliable references

FEBS J 280, 59575980

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Overall, the findings of this study suggest that the impact of the ketogenic diet on tumor growth is influenced by the type of dietary fat consumed, particularly saturated fatty acids, which, when abundant in the ketogenic diet, can decrease SCD activity and further inhibit tumor growth [91]