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The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable
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doi: 10.1016/0028-3908(72)90060-3
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2018;13:e0193918
A study by Walter-Sack, I., et al
